SENIOR PRINCIPAL SCIENTIST--TUMOR BIOLOGY

ROLE SUMMARYThe focus of this position is on translating basic discoveries in the field of cancer epigenetics and oncogenic transcriptional programming into novel therapeutics.As part of our Oncogenic Transcriptional Networks team in our Tumor Biology group, you will conduct biology discovery supporting existing and emerging drug discovery programs in the group, leading a team of scientists to perform laboratory-based research in a collaborative team environment.  As a leader of the group, you will be involved in evaluation of small molecule inhibitors, target mechanism-of-action studies, interpretation and presentation of data, and will function as an integral member of the project teams to advance programs.ROLE RESPONSIBILITIES Lead a laboratory research group to study genetic and epigenetic mechanisms in tumor biology with the aim to identify new therapeutic targets and approaches that can be translated to the clinicWork with interdisciplinary teams to advance small molecule drug discovery programs from early target validation through hit-to-lead campaigns.Utilize expertise in transcriptional regulation and epigenetic biology to design, execute, and analyze/interpret innovative approaches for epigenetic targeting in cancer.Work collaboratively with computational biology group to integrate complex data sets including epigenomic and other ‘omic’ data in pre-clinical settings for target discovery, validation, and advance mechanism of action target biologyLead development of cell and molecular assays to define target mechanism of action, measure pharmacodynamic changes and select responder patient populations.Interface with discovery biology and computational biology groups to design, develop, and interpret datasets developed from genetic and pharmacological screensProactively seek out new information in the literature and incorporate this into individual project(s) as well as the overall program.Present research results and methodologies at weekly meetings with immediate supervisor and/or project leader, and at meetings with members of the oncology research unit as appropriate.Contribute to building a culture that embraces scientific excellence, urgency, partnerships with key stakeholders, continuous learning and improvement, increasing technical skill base and cancer biology expertiseTake a proactive role in personal growth and scientific development.QUALIFICATIONS Must HavePhD or MD/PhD in Molecular Biology, Pharmacology or a relevant biological scienceMinimum of 7 years of relevant industry experience in a pharmaceutical/biotech environment.Extensive knowledge and experience in areas of tumor biology including chromatin biology, epigenetics, and mechanism of transcriptional regulation in cancer as evidenced by publication in peer-reviewed journals.Strong track record in conceptualizing and advancing small molecule drug discovery programsExperience leading and managing laboratory-based teams with familiarity with biological assays supporting drug discovery programsStrong track record of advancing drug discovery programs employing traditional small molecule inhibitors as well as emerging chemical proximity approaches such as protein degradersStrong written and verbal communication skillsNice to HaveExperience with the integration of molecular and epigenomic (e.g., ATAC-seq, ChIP-seq) datasets, into a broader understanding of target function**Proficiency in the use of software tools to support epigenomic data analysis including ATAC-seq, ChIP-seq, and RNA-seq.Experience in use of CRISPR-based techniques for gene knockout, gene editing, supporting model generation and target validations studiesExtensive experience in cancer biology including transcription factor regulation and the application of these therapeutic approaches in the clinical landscapeCandidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.Relocation support availableWork Location Assignment: On PremiseThe annual base salary for this position ranges from $131,200.00 to $218,600.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 17.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.Relocation assistance may be available based on business needs and/or eligibility.Sunshine ActPfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations.  These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure.  Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act.  Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government.  If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.EEO & Employment EligibilityPfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.  Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.  Pfizer is an E-Verify employer.  This position requires permanent work authorization in the United States.Research and DevelopmentSummaryLocation: United States - California - La JollaType: Full time